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GENLIFE SCIENCE

Tiede on tuotekehityksemme perustana. GenHealth perustuu vuosikymmenien ravitsemustieteen tutkimukseen. Innovaatiomme ei perustu uusiin (ja siksi usein vain pintapuolisesti tutkittuihin) ainesosiin. Me olemme valinneet pitkään ja monipuolisesti tutkitut mikroravintoaineet. Alla löydät listan julkaisuista, joita on käytetty tuotekehityksemme pohjana. Täydelliset tutkimusraportit löydät osoitteesta www.pubmed.gov

➤ A variant of the HTRA1 gene increases susceptibility to age- related macular degeneration. Science. 2006 Nov 10.314(5801):992-3. Epub 2006 Oct 19. Yang Z, Camp NJ, Sun H, Tong Z, Gibbs D, Cameron DJ, Chen H, Zhao Y, Pearson E, Li X, Chien J, Dewan A, Harmon J, Bernstein PS, Shridhar V, Zabriskie NA, Hoh J, Howes K, Zhang K.
➤ Adams PC, R.D., Barton JC, McLaren CE, Eckfeldt JH, McLaren GD, Dawkins FW, Acton RT, Harris EL, Gordeuk VR, Leiendecker-Foster C, Speechley M, Snively BM, Holup JL, Thomson E, Sholinsky P., Hemochromatosis and iron-overload screening in a racially diverse population. N Engl J Med, 2005(352): p. 1769–78.
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➤ Alpha-tocopherol supplementation prevents the exercise- induced reduction of serum paraoxonase 1/arylesterase activities in healthy individuals.
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➤ Antioxidant micronutrients and biomarkers of oxidative stress and inflammation in colorectal adenoma patients: results from a randomized, controlled clinical trial.
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➤ Jacques PF, Kalmbach R, Bagley PJ, et al. The relationship between riboflavin and plasma total homocysteine in the Framingham Offspring cohort is influenced by folate status and the C677T transition in the methylenetetrahydrofolate reductase gene. J Nutr. 2002;132(2):283-288.
➤ Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population.
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➤ Barry I. Posner2,12, David J. Balding13, David Meyre5, Constantin Polychronakos1,3 & Philippe Froguel5,14; A genome-wide association study
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➤ Bundeslebensmittelschlüssel (BLS)
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➤ CDCP, Centers for Disease Control and Prevention
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➤ Daniel Steinberg (2007). The Cholesterol Wars: The Cholesterol Skeptics vs the Preponderance of Evidence. Boston: Academic Press.

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➤ Deutsche Gesellschaft zur Bekämpfung von Fettstoffwechselstörungen und ihren Folgeerkrankungen DGFF e.V

➤ Deutsche Ophthalmologische Gesellschaft (DOG)

➤ Deutsche Zöliakie Gemeinschaft
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➤ Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease.
➤ Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease.
➤ Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older.Dawson-Hughes B: N Engl J Med. 1997 Sep 4;337(10):670-6.
➤ Effect of supplementation of calcium and vitamin D on bone mineral density and bone mineral content in peri- and post- menopause women; a double-blind, randomized, controlled trial.Di Daniele N,Pharmacol Res. 2004 Dec;50(6):637-41.
➤ Effective detection of human leukocyte antigen risk alleles in celiac disease using tag single nucleotide polymorphisms. Monsuur AJ, de Bakker PI, Zhernakova A, Pinto D, Verduijn W, Romanos J, Auricchio R, Lopez A, van Heel DA, Crusius JB, Wijmenga C. PLoS One. 2008 May 28.3(5):e2270.
➤ Ellard, S. : Hepatocyte nuclear factor 1 alpha (HNF-1-alpha) mutations in maturity-onset diabetes of the young. Hum. Mutat. 16: 377-385, 2000
➤ Enattah, N. S.; Sahi, T.; Savilahti, E.; Terwilliger, J. D.; Peltonen, L.; Jarvela, I. : Identification of a variant associated with adult-type hypolactasia. Nature Genet. 30: 233-237, 2002.
➤ Fajans, S. S.; Bell, G. I.; Polonsky, K. S. : Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. New Eng. J. Med. 345: 971-980, 2001.
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➤ Ferrari, S. L.; Deutsch, S.; Choudhury, U.; Chevalley, T.; Bonjour, J.-P.; Dermitzakis, E. T.; Rizzoli, R.; Antonarakis, S. E. : Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with variation in vertebral bone mass, vertebral bone size, and stature in whites. Am. J. Hum. Genet. 74: 866-875, 2004
➤ Fracture prevention with vitamin D supplementation: a meta- analysis of randomized controlled trials.JAMA. 2005 May 11;293(18):2257-64: Bischoff-Ferrari HA
➤ Froguel, P.; Velho, G.; Cohen, D.; Passa, P. : Strategies for the collection of sibling-pair data for genetic studies in type 2 (non insulin-dependent) diabetes mellitus. (Letter) Diabetologia 34: 685 only, 1991
➤ Ganz DA, Bao Y, Shekelle PG, Rubenstein LZ (2007). "Will my patient fall?". JAMA 297 (1): 77–86
➤ Gene-culture coevolution between cattle milk protein genes and human lactase genes. Nature Genet. 35: 311-313, 2003. Note: Erratum: Nature Genet. 35: 106 only, 2003.
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➤ Guéant-Rodriguez RM: Thromb Haemost. 2005 Sep;94(3):510-5
➤ Guideline der National Osteoporosis Foundation (USA), 2003
➤ Guillaume Charpentier8, Thomas J. Hudson4,9, Alexandre Montpetit4, Alexey V. Pshezhetsky10, Marc Prentki10,11,
➤ Gut 1989; 30: 333-338
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➤ HHEX gene polymorphisms are associated with type 2 diabetes in the Dutch Breda cohort. Europ. J. Hum. Genet. 16: 652-656, 2008

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➤ Klein, R. J.; Zeiss, C.; Chew, E. Y.; Tsai, J.-Y.; Sackler, R. S.; Haynes, C.; Henning, A. K.; SanGiovanni, J. P.; Mane, S. M.; Mayne, S. T.; Bracken, M. B.; Ferris, F. L.; Ott, J.; Barnstable, C.; Hoh, J. : Complement factor H polymorphism in age-related macular degeneration. Science 308: 385-389, 2005
➤ Kuokkanen, M.; Kokkonen, J.; Enattah, N. S.; Ylisaukko-oja, T.; Komu, H.; Varilo, T.; Peltonen, L.; Savilahti, E.; Jarvela, I. : Mutations in the translated region of the lactase gene (LCT) underlie congenital lactase deficiency. Am. J. Hum. Genet. 78: 339-344, 2006.

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macular degeneration. Nature Genet. 38: 1055-1059, 2006
➤ Manganese superoxide dismutase polymorphism and risk of gastric lesions, and its effects on chemoprevention in a Chinese population.Tu HK: Cancer Epidemiol Biomarkers Prev. 2010 Apr;19(4):1089-97. Epub 2010 Mar 16.
➤ Maternal MTHFR 677C>T genotype and dietary intake of folate and vitamin B(12): their impact on child neurodevelopment.del Río Garcia C: Nutr Neurosci. 2009 Feb;12(1):13-20.
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➤ MFMER, Mayo Foundation for Medical Education and Research.

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➤ NCEP, Nationales Cholesterin-Erziehungsprogramm
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➤ Selenium in cancer prevention: a review of the evidence and mechanism of action.
➤ Selenium supplementation increases liver MnSOD expression: molecular mechanism for hepato-protection.Shilo S: J Inorg Biochem. 2008 Jan;102(1):110-8. Epub 2007 Aug 1.
➤ Selenium supplementation restores the antioxidative capacity and prevents cell damage in bone marrow stromal cells in vitro.Ebert R: Stem Cells. 2006 May;24(5):1226-35. Epub 2006 Jan 19.

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